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Index > Protein center > DFFB(Gene name) > Human
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  • DFFB (Gene name),
  • DNA fragmentation factor subunit beta (Protein name ),  DFFB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DFFB(CAD;DFF2;DFF40);
    Protein name:
    DNA fragmentation factor subunit beta;
    Alternative:
    Caspase-activated nuclease(CPAN);Caspase-activated deoxyribonuclease(CAD;Caspase-activated DNase);DNA fragmentation factor 40 kDa subunit(DFF-40);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of DFFA and DFFB.
    Function:
    Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    338
    Sequence:
    50:
    MLQKPKSVKL | RALRSPRKFG | VAGRSCQEVL | RKGCLRFQLP | ERGSRLCLYE | 
    100:
    DGTELTEDYF | PSVPDNAELV | LLTLGQAWQG | YVSDIRRFLS | AFHEPQVGLI | 
    150:
    QAAQQLLCDE | QAPQRQRLLA | DLLHNVSQNI | AAETRAEDPP | WFEGLESRFQ | 
    200:
    SKSGYLRYSC | ESRIRSYLRE | VSSYPSTVGA | EAQEEFLRVL | GSMCQRLRSM | 
    250:
    QYNGSYFDRG | AKGGSRLCTP | EGWFSCQGPF | DMDSCLSRHS | INPYSNRESR | 
    300:
    ILFSTWNLDH | IIEKKRTIIP | TLVEAIKEQD | GREVDWEYFY | GLLFTSENLK | 
    338:
    LVHIVCHKKT | THKLNCDPSR | IYKPQTRLKR | KQPVRKRQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    SMR:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human DNA fragmentation factor subunit beta
    Cat.:
    E1058r
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    Packing:
    96T
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    ELISA Kit for Human DNA fragmentation factor subunit beta
    Cat.:
    E1058h
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    Packing:
    96T
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    ELISA Kit for Human DNA fragmentation factor subunit beta
    Cat.:
    E1058b
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    Packing:
    96T
    ELISA Kit for Human DNA fragmentation factor subunit beta
    Cat.:
    E1058m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DNA fragmentation factor subunit beta
    Cat.:
    U1058m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DNA fragmentation factor subunit beta
    Cat.:
    U1058r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DNA fragmentation factor subunit beta
    Cat.:
    U1058h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human DNA fragmentation factor subunit beta
    Cat.:
    U1058b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human DNA fragmentation factor subunit beta
    Polyclonal Antibody for Human DNA fragmentation factor subunit beta
    Cat.:
    P1058Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DNA fragmentation factor subunit beta
    Cat.:
    P1058Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DNA fragmentation factor subunit beta
    Cat.:
    P1058Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human DNA fragmentation factor subunit beta
    Monoclonal Antibody for Human DNA fragmentation factor subunit beta
    Monoclonal Antibody for Human DNA fragmentation factor subunit beta
    Monoclonal Antibody for Human DNA fragmentation factor subunit beta
    Protein for Human DNA fragmentation factor subunit beta
    Protein for Human DNA fragmentation factor subunit beta
    Protein for Human DNA fragmentation factor subunit beta
    Protein for Human DNA fragmentation factor subunit beta

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    References
    1. 1.
      "The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis."
      Liu X. , Li P. , Widlak P. , Zou H. , Luo X. , Garrard W.T. , Wang X.
      Proc. Natl. Acad. Sci. U.S.A.95:8461-8466(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
    2. 2.
      "Molecular cloning and characterization of human caspase-activated DNase."
      Mukae N. , Enari M. , Sakahira H. , Fukuda Y. , Inazawa J. , Toh H. , Nagata S.
      Proc. Natl. Acad. Sci. U.S.A.95:9123-9128(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
    3. 3.
      "CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45."
      Halenbeck R. , MacDonald H. , Roulston A. , Chen T.T. , Conroy L. , Williams L.T.
      Curr. Biol.8:537-540(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
      tissue: Pancreas.
    4. 4.
      "DFF40 delta."
      Nakagawara A. , Takahashi M. , Takada N. , Kawamoto T.
      Submitted (1999-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BETA; GAMMA AND DELTA)
      tissue: Fetal brain.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
      tissue: Lung.
    8. 8.
      "An unappreciated role for RNA surveillance."
      Hillman R.T. , Green R.E. , Brenner S.E.
      Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
    9. 9.
      "Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells."
      Ninios Y.P. , Sekeri-Pataryas K.E. , Sourlingas T.G.
      Apoptosis15:128-138(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIST1H1A
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Structure and mutation analysis of the gene encoding DNA fragmentation factor 40 (caspase-activated nuclease), a candidate neuroblastoma tumour suppressor gene."
      Judson H. , van Roy N. , Strain L. , Vandesompele J. , Van Gele M. , Speleman F. , Bonthron D.T.
      Hum. Genet.106:406-413(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-196
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